Anti-TET2抗體,甲基雙加氧酶TET2抗體技術標準
Catalog Number : BYK-9449R
Quantity size : 0.1ml （dilute with pH 7.4 0.01 M PBS or antibody diluent ）
Background: TET2 is a 2,002 amino acid protein that is expressed in a variety of tissues, including brain, kidney, heart, lung, muscle and stomach, and exists as three alternatively spliced isoforms. Murine TET2 is also known as protein Ayu17-449 and is thought to play a role in proper kidney development and overall kidney function, as well as in hormone secretion throughout the body. The gene encoding human TET2 maps to chromosome 4 and the gene encoding mouse TET2 maps to chromosome 3. Chromosome 4 encodes nearly 6% of the human genome and has the largest gene deserts （regions of the genome with no protein encoding genes） of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Murine chromosome 3 houses over 1,300 genes, some of which express alcohol dehydrogenases （ADHs）, sodium channel modifiers （SCNMs）, interleukins （ILs） and Insulin receptor-related （IRR） proteins. Defects in chromosome 3-localized genes are associated with hereditary congenital facial paresis （HCFP）, increased susceptibility to spontaneous colitis, HIV-1-associated nephropathy, decreased renal vascular health and malignant sporadic pancreatic endocrine tumors.
Anti-TET2抗體,甲基雙加氧酶TET2抗體技術標準Specificity :
– Anti-TET2 is a rabbit polyclonal antibody unconjugated
– specific forTET2 of hu,rb,rat
– use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 216kDa
Application :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– IHC-P=1:100-500 IHC-F=1:100-500
– ELISA 1:500-1000 IF=1:50-200
– Optimal working dilutions must be determined by the end user.
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Anti-TET2抗體,甲基雙加氧酶TET2抗體技術標準Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
