Anti-CEA
 

產(chǎn)品類別產(chǎn)品目錄>> 一抗>> 一抗
 

產(chǎn)品編號by-0719R
英文名稱Anti-CEA
中文名稱癌胚抗原抗體
別名
CEA ;Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5;
CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100; Ceacam3; Cear; Cgm1;
Cgm4; CGM4AA; MGC114355; RATCEAA; RATCGM4AA.
 

產(chǎn)品價(jià)格0.1ml/100μg/780元0.2ml/200μg/1100元1mg/1mg/3260元
 

濃度1mg/1ml
抗體來源Rabbit
克隆類型polyclonal
交叉反應(yīng)hu
產(chǎn)品類型一抗
 

研究領(lǐng)域腫瘤細(xì)胞類型標(biāo)志物
蛋白分子量predicted molecular weight: 150-200kDa
性狀Lyophilized or Liquid
免疫原KLH conjugated synthetic peptide derived from human CEA N-terminus
亞型IgG
 

純化方法affinity purified by Protein A
儲存液0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
 

產(chǎn)品應(yīng)用
 

WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500
Flow-Cyt=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
 

保存條件
 

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody
is stable at room temperature for at least one month and for greater than a year when kept
at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody
is stable for at least two weeks at 2-4 °C.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic
or diagnostic applications.
 

Anti-CEA
產(chǎn)品介紹
 

CEA-related cell adhesion molecules （CEACAM） belong to the carcinoembryonic antigen （CEA）
family. It consists of seven CEACAM （CEACAM 1, CEACAM 3-CEACAM 8） and 11 pregnancy-specific
glyco-protein （PSG 1-PSG 11） members. The CEA family proteins belong to the immunoglobulin
（Ig） superfamily and are composed of one Ig variable-like （IgV） and a varying number （0-6）
of Ig constant-like （IgC） domains. CEACAM molecules are membrane-bound either via a
transmembrane domain or a glycosyl phosphatidyl inositol （GPI） anchor. CEACAM molecules are
differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM
5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The
function of CEACAM family members varies widely: they function as cell adhesion molecules,
tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of
Neisseria species and other bacteria.
Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity : Found in adenocarcinomas of endodermally derived digestive system
epithelium and fetal colon.
Similarity : Belongs to the immunoglobulin superfamily. CEA family.
Contains 7 Ig-like （immunoglobulin-like） domains.
Subunit : Homodimer.
 

CEA 是一種胚胎性抗原，主要存在于胎兒消化道上皮組織，胰腺和肝癌中。CEA 廣泛存在各種上皮性腫
瘤，尤其是胃腸道惡性腫瘤，CEA 分布陽性類型與腫瘤的惡性度有關(guān)。CEA 與EMA 一樣可作為上皮性惡
性腫瘤的重要標(biāo)記。

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